Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18551846 | 0.82 | DAO (0.59) | DAO | |
| SCHEMBL25566539 | 0.81 | CALM1 (0.48) | DAO | |
| SCHEMBL20382591 | 0.81 | SKP2 (0.56) | HTR2ADAO | |
| SCHEMBL257778 | 0.80 | MRGPRX4 (0.53) | MAOAMAOB | |
| SCHEMBL8747545 | 0.79 | DAO (0.46) | IGF1RALOX15DAOCHRM5CHRM1 | |
| SCHEMBL586296 | 0.79 | DAO (0.46) | IGF1RALOX15DAOCHRM5CHRM1 | |
| SCHEMBL17547998 | 0.79 | DAO (0.53) | IGF1RALOX15DAO | |
| SCHEMBL15682762 | 0.79 | DAO (0.49) | ALOX15DAO | |
| SCHEMBL7857328 | 0.78 | DAO (0.45) | HTR2AIGF1RALOX15DAOCHRM5 | |
| SCHEMBL16502363 | 0.78 | HTR2A (0.47) | HTR2AIGF1RALOX15MAOBNOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2404607-A1 | Boronic acids and esters as inhibitors of fatty acid amide hydrolase | Infinity Pharmaceuticals, Inc. (US) | 2012-01-11 | — | — | EP | disclosed |
| EP-2399585-A1 | Boronic acids and esters as inhibitors of fatty acid amide hydrolase | Infinity Pharmaceuticals, Inc. (US) | 2011-12-28 | — | — | EP | disclosed |
| EP-2073816-B1 | BORONIC ACIDS AND ESTERS AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE | INFINITY PHARMACEUTICALS INC (US) | 2011-09-14 | — | — | EP | disclosed |