Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 7/20 | 0.39 |
| ▸ | BRAF | P15056 | 5/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | WEE1 | P30291 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL231015 | 0.85 | BRAF (0.39) | SRCBRAFDDR2 | |
| SCHEMBL230427 | 0.80 | SRC (0.45) | SRCFGFR4BRAFWEE1DGAT1 | |
| SCHEMBL230426 | 0.80 | SRC (0.45) | SRCFGFR4BRAFWEE1DGAT1 | |
| SCHEMBL2573807 | 0.71 | SRC (0.53) | SRCFGFR4BRAFFGFR1WEE1 | |
| SCHEMBL230249 | 0.70 | SRC (0.77) | SRCBRAFFGFR1CYP3A4CYP2D6 | |
| SCHEMBL2573809 | 0.69 | YES1 (0.53) | SRCFGFR4BRAFFGFR1 | |
| SCHEMBL5501154 | 0.69 | SRC (0.69) | SRCBRAFFGFR1CYP3A4CYP2D6 | |
| SCHEMBL226165 | 0.68 | SRC (0.55) | SRCBRAFFGFR1CYP3A4CYP2D6 | |
| SCHEMBL226164 | 0.68 | SRC (0.55) | SRCBRAFFGFR1CYP3A4CYP2D6 | |
| SCHEMBL5501445 | 0.68 | MAP4K1 (0.64) | SRCFGFR4FGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2381943-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS | Fovea Pharmaceuticals (FR) | 2011-11-02 | — | — | EP | claimed |
| WO-2010076238-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS | FOVEA PHARMACEUTICALS SA (FR) | 2010-07-08 | — | — | WO | claimed |