⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26724876 | 0.85 | LMNA (0.35) | — | |
| SCHEMBL26724878 | 0.83 | LMNA (0.39) | — | |
| SCHEMBL8438207 | 0.82 | — | — | |
| SCHEMBL28002589 | 0.81 | LMNA (0.37) | — | |
| SCHEMBL4947867 | 0.81 | ALDH1A1 (0.44) | — | |
| SCHEMBL29091867 | 0.80 | LMNA (0.36) | — | |
| Butane SCHEMBL10594290 | 0.77 | ALDH1A1 (0.37) | — | |
| SCHEMBL28482449 | 0.75 | ALDH1A1 (0.39) | — | |
| SCHEMBL11757770 | 0.75 | ALDH1A1 (0.39) | — | |
| SCHEMBL11999098 | 0.73 | ALDH1A1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11873291-B2 | Quinoline cGAS antagonist compounds | IMMUNESENSOR THERAPEUTICS, INC. (US) | 2024-01-16 | — | — | US | disclosed |
| US-20230357158-A1 | QUINOLINE cGAS ANTAGONIST COMPOUNDS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2023-11-09 | — | — | US | disclosed |
| US-20230212148-A1 | THERAPEUTIC COMPOUNDS FOR HIV VIRUS INFECTION | GILEAD SCIENCES, INC. | 2023-07-06 | — | — | US | disclosed |