Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR2 | P37173 | 3/20 | 0.51 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 12/20 | 0.45 |
| ▸ | FLT1 | P17948 | 3/20 | 0.45 |
| ▸ | FLT4 | P35916 | 3/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | MARK3 | P27448 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13822288 | 0.80 | KDR (0.68) | TGFBR2ACVR2AKDRFLT1FLT4 | |
| SCHEMBL22834516 | 0.80 | TGFBR2 (0.50) | TGFBR2ACVR2AKDRFLT1FLT4 | |
| SCHEMBL15308505 | 0.76 | PDE2A (0.41) | TGFBR2ACVR2AKDRFLT1FLT4 | |
| SCHEMBL17052954 | 0.76 | TGFBR2 (0.47) | TGFBR2ACVR2AKDRFLT1FLT4 | |
| SCHEMBL359148 | 0.76 | HSD11B1 (0.52) | TGFBR2ACVR2AKDRFLT1FLT4 | |
| SCHEMBL22834740 | 0.75 | HSD11B1 (0.43) | TGFBR2ACVR2AKDRFLT1FLT4 | |
| SCHEMBL28979830 | 0.73 | KDR (0.33) | KDRFLT1FLT4PLK4AURKA | |
| SCHEMBL25791703 | 0.73 | KDR (0.36) | KDRFLT1FLT4PLK4AURKA | |
| SCHEMBL13960990 | 0.73 | KDR (0.37) | KDRFLT1FLT4PLK4AURKA | |
| SCHEMBL23728470 | 0.73 | ALDH1A1 (0.54) | HSD11B1PDE2AIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023130054-A2 | HETEROARYL COMPOUNDS AS INHIBITORS OF IRAK4, COMPOSITIONS AND APPLICATIONS THEREOF | ACCRO BIOSCIENCE (HK) LIMITED (CN) | 2023-07-06 | — | — | WO | disclosed |