Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 10/20 | 0.47 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | MGAM | O43451 | 9/20 | 0.44 |
| ▸ | AMY1A | P0DUB6 | 9/20 | 0.44 |
| ▸ | SI | P14410 | 9/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 9/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | F12 | P00748 | 6/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20850940 | 0.78 | DGAT1 (0.50) | DGAT1GAAF2MGAMAMY1A | |
| SCHEMBL14362020 | 0.77 | DGAT1 (0.61) | DGAT1GAAF2MGAMAMY1A | |
| SCHEMBL19824210 | 0.77 | DGAT1 (0.49) | DGAT1GAAF2MGAMAMY1A | |
| SCHEMBL20108539 | 0.75 | DGAT1 (0.47) | DGAT1GAAF2MGAMAMY1A | |
| SCHEMBL5490033 | 0.75 | GAA (0.62) | DGAT1GAAF2MGAMAMY1A | |
| SCHEMBL23110047 | 0.73 | DGAT1 (0.49) | DGAT1GAAF2MGAMAMY1A | |
| SCHEMBL15426053 | 0.73 | DGAT1 (0.66) | DGAT1GAAF2MGAMAMY1A | |
| SCHEMBL21736909 | 0.73 | DGAT1 (0.51) | DGAT1GAAF2MGAMAMY1A | |
| SCHEMBL17987937 | 0.73 | DGAT1 (0.59) | DGAT1GAAF2MGAMAMY1A | |
| SCHEMBL19496157 | 0.73 | DGAT1 (0.59) | DGAT1GAAF2MGAMAMY1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192607-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192607-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | TEAD1, TEAD4, TEAD2 | DGAT1 2310/4885GAA 3205/4885F2 3291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.