Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27476106 | 0.82 | KCNH2 (0.52) | KCNH2AKT1AKT2FDPSLMNA | |
| SCHEMBL25798414 | 0.80 | NPBWR1 (0.44) | NPBWR1KCNH2AKT1AKT2FDPS | |
| SCHEMBL30549950 | 0.80 | NPBWR1 (0.44) | NPBWR1KCNH2AKT1AKT2FDPS | |
| SCHEMBL20040983 | 0.80 | NPBWR1 (0.44) | NPBWR1KCNH2AKT1AKT2FDPS | |
| SCHEMBL16054951 | 0.80 | NPBWR1 (0.44) | NPBWR1KCNH2AKT1AKT2FDPS | |
| SCHEMBL12583213 | 0.78 | NOTUM (0.50) | NOTUMIKBKB | |
| SCHEMBL26375464 | 0.78 | NOTUM (0.50) | NOTUMIDO1IKBKB | |
| SCHEMBL28182653 | 0.76 | KCNH2 (0.54) | KCNH2AKT1AKT2FDPSLMNA | |
| SCHEMBL13949153 | 0.76 | NOTUM (0.49) | NOTUMIDO1IKBKB | |
| SCHEMBL2996698 | 0.75 | RXRA (0.50) | NPBWR1KCNH2AKT1AKT2FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023109912-A1 | 3, 4-DIHYDROISOQUINOLIN-1 (2H) -ONES DERIVATIVES AS STING ANTAGONISTS AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2023-06-22 | — | — | WO | disclosed |