SCHEMBL2579537

SCHEMBL2579537

C=CC(c1ccccc1)N1CCN(C(C=C)c2ccccc2)CC1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 7/20 0.48
KCNH2 Q12809 6/20 0.44
OPRM1 P35372 3/20 0.44
CHRM2 P08172 2/20 0.44
CHRM4 P08173 2/20 0.44
CHRM5 P08912 2/20 0.44
ADRA2A P08913 2/20 0.44
ADORA3 P0DMS8 2/20 0.44
CHRM1 P11229 2/20 0.44
CHRM3 P20309 2/20 0.44
DRD1 P21728 2/20 0.44
ADRA1D P25100 2/20 0.44
HTR2A P28223 2/20 0.44
HRH1 P35367 2/20 0.44
DRD3 P35462 2/20 0.44
HTR2B P41595 2/20 0.44
SLC6A3 Q01959 2/20 0.44
HTR2C P28335 1/20 0.44
CYP3A4 P08684 6/20 0.43
CYP1A2 P05177 5/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11645727 0.92 CHRM2 (0.56) CYP2D6KCNH2OPRM1CHRM2CHRM4
SCHEMBL29078136 0.92 CHRM2 (0.56) CYP2D6KCNH2OPRM1CHRM2CHRM4
SCHEMBL3294321 0.92 CYP2D6 (0.55) CYP2D6KCNH2OPRM1CHRM2CHRM4
SCHEMBL986928 0.91 CYP2D6 (0.59) CYP2D6KCNH2OPRM1CHRM2CHRM4
SCHEMBL6838012 0.90 CYP1A2 (0.57) CYP2D6KCNH2CYP3A4CYP1A2CYP2C9
SCHEMBL6837651 0.90 CYP1A2 (0.57) CYP2D6KCNH2CYP3A4CYP1A2CYP2C9
SCHEMBL30518149 0.90 CYP1A2 (0.57) CYP2D6KCNH2CYP3A4CYP1A2CYP2C9
SCHEMBL2361182 0.90 CYP1A2 (0.57) CYP2D6KCNH2CYP3A4CYP1A2CYP2C9
SCHEMBL11136769 0.90 CYP1A2 (0.57) CYP2D6KCNH2CYP3A4CYP1A2CYP2C9
SCHEMBL6837652 0.90 CYP1A2 (0.57) CYP2D6KCNH2CYP3A4CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1978959-B1 PIPERIDINE AND PIPERAZINE DERIVATIVES MS SCIENCE CORP (JP) 2011-11-09 EP disclosed