Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 15/20 | 0.60 |
| ▸ | NLRP3 | Q96P20 | 9/20 | 0.58 |
| ▸ | TNF | P01375 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25798530 | 1.00 | IL1B (0.60) | IL1BNLRP3TNFKCNH2 | |
| SCHEMBL25798527 | 0.89 | NLRP3 (0.60) | IL1BNLRP3 | |
| SCHEMBL25798438 | 0.87 | IL1B (0.75) | IL1BNLRP3 | |
| SCHEMBL25798660 | 0.87 | IL1B (0.56) | IL1BNLRP3KCNH2 | |
| SCHEMBL25298003 | 0.87 | IL1B (0.75) | IL1BNLRP3 | |
| SCHEMBL25298002 | 0.87 | IL1B (0.75) | IL1BNLRP3 | |
| SCHEMBL30519498 | 0.87 | IL1B (0.75) | IL1BNLRP3 | |
| SCHEMBL31021472 | 0.86 | IL1B (0.63) | IL1BNLRP3TNF | |
| SCHEMBL25798129 | 0.85 | IL1B (0.59) | IL1BNLRP3TNFKCNH2 | |
| SCHEMBL25798590 | 0.84 | IL1B (0.44) | IL1BNLRP3TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129987-A1 | PYRIDAZINE DERIVATIVES AS MODULATORS OF NLRP3 INFLAMMASOME AND RELATED METHODS | Neumora Therapeutics, Inc. (US) | 2023-07-06 | — | — | WO | disclosed |