Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 12/20 | 0.61 |
| ▸ | NLRP3 | Q96P20 | 10/20 | 0.61 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25797819 | 0.89 | NLRP3 (0.65) | IL1BNLRP3 | |
| SCHEMBL25798054 | 0.89 | IL1B (0.56) | IL1BNLRP3 | |
| SCHEMBL25797812 | 0.87 | NLRP3 (0.78) | IL1BNLRP3 | |
| SCHEMBL25798335 | 0.87 | NLRP3 (0.68) | IL1BNLRP3 | |
| SCHEMBL25798457 | 0.87 | IL1B (0.74) | IL1BNLRP3 | |
| SCHEMBL25798059 | 0.86 | NLRP3 (0.65) | IL1BNLRP3 | |
| SCHEMBL25798309 | 0.86 | NLRP3 (0.74) | IL1BNLRP3 | |
| SCHEMBL25797798 | 0.85 | NLRP3 (0.61) | IL1BNLRP3 | |
| SCHEMBL25797908 | 0.85 | NLRP3 (0.70) | IL1BNLRP3 | |
| SCHEMBL25298002 | 0.84 | IL1B (0.75) | IL1BNLRP3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129987-A1 | PYRIDAZINE DERIVATIVES AS MODULATORS OF NLRP3 INFLAMMASOME AND RELATED METHODS | Neumora Therapeutics, Inc. (US) | 2023-07-06 | — | — | WO | disclosed |