Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 11/20 | 0.60 |
| ▸ | IL1B | P01584 | 9/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25798433 | 0.90 | NLRP3 (0.60) | NLRP3IL1BKCNH2TNF | |
| SCHEMBL25797915 | 0.89 | IL1B (0.58) | NLRP3IL1BKCNH2TNF | |
| SCHEMBL25798431 | 0.88 | NLRP3 (0.58) | NLRP3IL1BKCNH2TNF | |
| SCHEMBL25798176 | 0.88 | NLRP3 (0.60) | NLRP3IL1BKCNH2TNF | |
| SCHEMBL25798381 | 0.87 | NLRP3 (0.57) | NLRP3IL1BKCNH2TNF | |
| SCHEMBL26772191 | 0.86 | NLRP3 (0.67) | NLRP3IL1BKCNH2TNF | |
| SCHEMBL25797812 | 0.86 | NLRP3 (0.78) | NLRP3IL1B | |
| SCHEMBL25798452 | 0.82 | NLRP3 (0.61) | NLRP3IL1BCHRM1 | |
| SCHEMBL25798896 | 0.82 | NLRP3 (0.68) | NLRP3IL1B | |
| SCHEMBL25798527 | 0.81 | NLRP3 (0.60) | NLRP3IL1BKAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129987-A1 | PYRIDAZINE DERIVATIVES AS MODULATORS OF NLRP3 INFLAMMASOME AND RELATED METHODS | Neumora Therapeutics, Inc. (US) | 2023-07-06 | — | — | WO | disclosed |