Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 13/20 | 0.70 |
| ▸ | IL1B | P01584 | 11/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26647736 | 0.90 | IL1B (0.77) | NLRP3IL1B | |
| SCHEMBL25798269 | 0.90 | NLRP3 (0.66) | NLRP3IL1B | |
| SCHEMBL26772247 | 0.89 | NLRP3 (0.74) | NLRP3IL1B | |
| SCHEMBL25798654 | 0.87 | NLRP3 (0.63) | NLRP3IL1B | |
| SCHEMBL25798265 | 0.87 | NLRP3 (0.63) | NLRP3IL1B | |
| SCHEMBL25798059 | 0.87 | NLRP3 (0.65) | NLRP3IL1B | |
| SCHEMBL24575305 | 0.86 | NLRP3 (0.75) | NLRP3IL1B | |
| SCHEMBL29696876 | 0.86 | NLRP3 (0.75) | NLRP3IL1B | |
| SCHEMBL26938723 | 0.86 | NLRP3 (0.75) | NLRP3IL1B | |
| SCHEMBL25798436 | 0.85 | IL1B (0.84) | NLRP3IL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129987-A1 | PYRIDAZINE DERIVATIVES AS MODULATORS OF NLRP3 INFLAMMASOME AND RELATED METHODS | Neumora Therapeutics, Inc. (US) | 2023-07-06 | — | — | WO | disclosed |