Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ATF4 | P18848 | 13/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22956410 | 0.94 | TDP1 (0.39) | ALDH1A1TDP1ATF4SCN9AKMT2A | |
| SCHEMBL25796969 | 0.90 | TDP1 (0.43) | ALDH1A1TDP1ATF4KMT2ARXFP1 | |
| SCHEMBL22627559 | 0.88 | ATF4 (0.41) | ALDH1A1TDP1ATF4 | |
| SCHEMBL22627582 | 0.88 | ALDH1A1 (0.42) | ALDH1A1TDP1ATF4KMT2A | |
| SCHEMBL22627715 | 0.88 | TDP1 (0.41) | ALDH1A1TDP1ATF4KMT2ARXFP1 | |
| SCHEMBL25806061 | 0.87 | TDP1 (0.43) | ALDH1A1TDP1ATF4KMT2ARXFP1 | |
| SCHEMBL22627649 | 0.86 | TDP1 (0.56) | ALDH1A1TDP1ATF4KMT2ARXFP1 | |
| SCHEMBL22627859 | 0.85 | ALDH1A1 (0.46) | ALDH1A1ATF4KMT2A | |
| SCHEMBL22627687 | 0.85 | ALDH1A1 (0.42) | ALDH1A1ATF4PTGES | |
| SCHEMBL22627592 | 0.84 | ATF4 (0.41) | ALDH1A1TDP1ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |