Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 5/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.45 |
| ▸ | PLG | P00747 | 2/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21753253 | 0.91 | ACACB (0.46) | ABCB1HRH3HPGDS1PR1ESR1 | |
| SCHEMBL5257657 | 0.88 | ALDH1A1 (0.47) | ABCB1HPGDS1PR1ESR1ESR2 | |
| SCHEMBL29098116 | 0.85 | HPGD (0.49) | HRH3HPGDS1PR1ESR1ESR2 | |
| SCHEMBL1265523 | 0.83 | NR1H2 (0.67) | ABCB1HRH3HPGDESR1ESR2 | |
| SCHEMBL27538580 | 0.80 | HRH3 (0.52) | HRH3HPGDESR1ESR2F10 | |
| SCHEMBL5137232 | 0.80 | HRH3 (0.58) | ABCB1HRH3HPGDABHD6F10 | |
| SCHEMBL30290475 | 0.80 | HRH3 (0.52) | HRH3S1PR1ESR1ESR2ABHD6 | |
| SCHEMBL11295872 | 0.79 | ESR1 (0.71) | ABCB1HPGDESR1ESR2ABHD6 | |
| SCHEMBL28533346 | 0.79 | HRH3 (0.57) | HRH3HPGDESR1ESR2F10 | |
| SCHEMBL29098077 | 0.78 | GAA (0.50) | ABCB1HRH3ESR1ESR2ABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101346353-B | Sulfonamide derivatives and their use in modulating metalloproteases | SERONO LAB | 2012-01-11 | — | — | CN | disclosed |
| EP-1951674-B1 | SULFONAMIDE DERIVATIVES AND USE THEREOF FOR THE MODULATION OF METALLOPROTEINASES | MERCK SERONO SA (CH) | 2011-11-23 | — | — | EP | disclosed |
| CN-101346353-A | Sulfonamide derivatives and their use in modulating metalloproteases | SERONO LAB (CH) | 2009-01-14 | — | — | CN | disclosed |