Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25903824 | 0.90 | HRH3 (0.71) | HRH3ABCB1KMT2AF10HPGD | |
| SCHEMBL28533346 | 0.88 | HRH3 (0.57) | HRH3KMT2AF10HPGDTSHR | |
| SCHEMBL30290475 | 0.84 | HRH3 (0.52) | HRH3KMT2AF10ABHD6 | |
| SCHEMBL27538580 | 0.84 | HRH3 (0.52) | HRH3KMT2AF10HPGDTSHR | |
| SCHEMBL1266229 | 0.84 | NR1H2 (0.63) | HRH3ABCB1KMT2AF10MGLL | |
| SCHEMBL28539714 | 0.83 | ESR1 (0.52) | HRH3KMT2AHPGDTSHRSMN1; SMN2 | |
| SCHEMBL14320109 | 0.82 | HRH3 (0.81) | HRH3 | |
| SCHEMBL27197550 | 0.81 | HRH3 (0.64) | HRH3SMN1; SMN2 | |
| SCHEMBL23701210 | 0.81 | HRH3 (0.49) | HRH3KMT2AF10ABHD6 | |
| SCHEMBL29097886 | 0.80 | HRH3 (0.53) | HRH3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951674-A1 | SULFONAMIDE DERIVATIVES AND USE THEREOF FOR THE MODULATION OF METALLOPROTEINASES | LABORATOIRES SERONO S.A. (CH) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007048788-A1 | SULFONAMIDE DERIVATIVES AND USE THEREOF FOR THE MODULATION OF METALLOPROTEINASES | LABORATOIRES SERONO S.A. (CH) | 2007-05-03 | — | — | WO | disclosed |