SCHEMBL25801632

SCHEMBL25801632

COc1ccc(CC(=N)NO)cc1Cl

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.48
ALDH1A1 P00352 3/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
SMN1; SMN2 Q16637 3/20 0.46
GAA P10253 1/20 0.43
PDE5A O76074 3/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
TTR P02766 1/20 0.42
KDM1A O60341 1/20 0.41
MAOA P21397 1/20 0.41
MAOB P27338 1/20 0.41
LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29844344 1.00 HSD17B10 (0.48) HSD17B10ALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL836980 0.80 IDO1 (0.47) KMT2A
SCHEMBL3119367 0.79 ALDH1A1 (0.59) ALDH1A1GAATTRLMNA
SCHEMBL25801611 0.79 ALDH1A1 (0.39) ALDH1A1SMN1; SMN2GAACA1CA2
SCHEMBL29844275 0.79 ALDH1A1 (0.39) ALDH1A1SMN1; SMN2GAACA1CA2
SCHEMBL7896877 0.78 ALDH1A1 (0.56) HSD17B10ALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL3777114 0.77 MEN1 (0.41) ALDH1A1MEN1KMT2ASMN1; SMN2GAA
SCHEMBL29844260 0.77 MEN1 (0.41) ALDH1A1MEN1KMT2ASMN1; SMN2GAA
SCHEMBL921998 0.76 GAA (0.68) HSD17B10ALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL3616256 0.76 ALDH1A1 (0.53) HSD17B10ALDH1A1MEN1KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230219907-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES SITRYX THERAPEUTICS LIMITED (GB) 2023-07-13 US disclosed
US-20230219907-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES SITRYX THERAPEUTICS LIMITED (GB) 2023-07-13 US disclosed
CN-115066418-A Carboxy derivatives with anti-inflammatory properties 西特瑞治疗有限公司 2022-09-16 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230219907-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES CPA2, RO60, C5AR1 HSD17B10 2079/4885ALDH1A1 134/4885MEN1 4504/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.