Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 11/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.33 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2585472 | 1.00 | OPRK1 (0.36) | OPRK1OPRM1OPRD1GRM2RAB9A | |
| SCHEMBL9999451 | 1.00 | OPRK1 (0.36) | OPRK1OPRM1OPRD1GRM2RAB9A | |
| SCHEMBL2585476 | 1.00 | OPRK1 (0.36) | OPRK1OPRM1OPRD1GRM2RAB9A | |
| SCHEMBL15088286 | 0.88 | ALDH1A1 (0.37) | OPRK1OPRM1OPRD1RAB9A | |
| SCHEMBL14960553 | 0.86 | GAA (0.37) | OPRK1OPRM1OPRD1RAB9A | |
| SCHEMBL20879833 | 0.86 | GAA (0.37) | OPRK1OPRM1OPRD1RAB9A | |
| SCHEMBL19151894 | 0.86 | GAA (0.37) | OPRK1OPRM1OPRD1RAB9A | |
| SCHEMBL13327003 | 0.86 | GAA (0.37) | OPRK1OPRM1OPRD1RAB9A | |
| SCHEMBL18532628 | 0.86 | ALDH1A1 (0.36) | — | |
| SCHEMBL12176092 | 0.86 | ALDH1A1 (0.41) | OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585064-A1 | C5AR ANTAGONISTS | ChemoCentryx, Inc. (US) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011163640-A1 | C5AR ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2011-12-29 | — | — | WO | disclosed |
| EP-2381778-A1 | C5AR ANTAGONISTS | ChemoCentryx, Inc. (US) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010075257-A1 | C5AR ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2010-07-01 | — | — | WO | disclosed |