Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 11/20 | 0.85 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.85 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24811431 | 1.00 | KEAP1 (0.85) | KEAP1NFE2L2NOTUMKDM4EALDH1A1 | |
| SCHEMBL17599442 | 0.92 | KEAP1 (1.00) | KEAP1NFE2L2NOTUMKDM4EALDH1A1 | |
| SCHEMBL17599452 | 0.92 | KEAP1 (1.00) | KEAP1NFE2L2NOTUMKDM4EALDH1A1 | |
| SCHEMBL17599491 | 0.92 | KEAP1 (1.00) | KEAP1NFE2L2NOTUMKDM4EALDH1A1 | |
| SCHEMBL29584677 | 0.92 | KEAP1 (1.00) | KEAP1NFE2L2NOTUMKDM4EALDH1A1 | |
| SCHEMBL24811433 | 0.89 | KEAP1 (0.89) | KEAP1NFE2L2NOTUMKDM4EALDH1A1 | |
| SCHEMBL25802756 | 0.88 | KEAP1 (0.78) | KEAP1NFE2L2NOTUM | |
| SCHEMBL24812643 | 0.88 | KEAP1 (0.78) | KEAP1NFE2L2NOTUM | |
| SCHEMBL24812743 | 0.87 | KEAP1 (0.87) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17599488 | 0.87 | KEAP1 (0.89) | KEAP1NFE2L2NOTUMKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122298-A1 | PROTEIN STABILIZING COMPOUNDS CONTAINING USP28 AND/OR USP25 TARGETING LIGANDS | Stablix, Inc. (US) | 2023-06-29 | — | — | WO | disclosed |