Sugi Predict

Sugi Predict / Compounds / SCHEMBL25804329

SCHEMBL25804329

SCHEMBL25804329

CCOP(=O)(OCC)C(Cc1nc(Cc2ccc(Cl)cc2)no1)C(=O)OC(C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.41
▸ TSHR P16473 2/20 0.40
▸ ZAP70 P43403 2/20 0.38
▸ SRC P12931 1/20 0.38
▸ MAPK1 P28482 2/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ OPRK1 P41145 1/20 0.34
▸ ERCC1 P07992 1/20 0.34
▸ ERCC4 Q92889 1/20 0.34
▸ TRPA1 O75762 2/20 0.34
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ SMPD1 P17405 1/20 0.33
▸ LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23588157 1.00 MAPT (0.41) MAPTTSHRZAP70SRCMAPK1
SCHEMBL25804685 0.97 MAPT (0.40) MAPTTSHRZAP70SRCMAPK1
SCHEMBL25801748 0.92 MAPT (0.41) MAPTTSHRZAP70SRCMAPK1
SCHEMBL23578499 0.92 TRPA1 (0.37) MAPTL3MBTL1TRPA1LMNA
SCHEMBL25805969 0.91 MEN1 (0.33) MAPTZAP70SRCL3MBTL1KDM4E
SCHEMBL23578356 0.91 MEN1 (0.33) MAPTTSHRZAP70SRCMEN1
SCHEMBL25804590 0.91 KMT2A (0.35) MAPTTSHRZAP70SRCALDH1A1
SCHEMBL25804614 0.91 HMGCR (0.34) MAPTTSHRZAP70SRCALDH1A1
SCHEMBL25804964 0.90 SIRT2 (0.33) MAPTZAP70SRCALDH1A1TRPA1
SCHEMBL23578557 0.90 TSHR (0.44) MAPTTSHRZAP70SRCMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240018111-A1 ALPHA, BETA UNSATURATED METHACRYLIC ESTERS WITH ANTI-INFLAMMATORY PROPERTIES SITRYX THERAPEUTICS LIMITED (GB) 2024-01-18 — — US disclosed
US-20240018111-A1 ALPHA, BETA UNSATURATED METHACRYLIC ESTERS WITH ANTI-INFLAMMATORY PROPERTIES SITRYX THERAPEUTICS LIMITED (GB) 2024-01-18 — — US disclosed
US-20230219907-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES SITRYX THERAPEUTICS LIMITED (GB) 2023-07-13 — — US disclosed
EP-4192821-A1 ALPHA,BETA UNSATURATED METHACRYLIC ESTERS WITH ANTI-INFLAMMATORY PROPERTIES Sitryx Therapeutics Limited (GB) 2023-06-14 — — EP disclosed
EP-4081511-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMMATORY PROPERTIES Sitryx Therapeutics Limited (GB) 2022-11-02 — — EP disclosed
CN-115066418-A Carboxy derivatives with anti-inflammatory properties 西特瑞治疗有限公司 2022-09-16 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230219907-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES CPA2, RO60, C5AR1 MAPT 4683/4885TSHR 3550/4885ZAP70 3409/4885
US-20240018111-A1 ALPHA, BETA UNSATURATED METHACRYLIC ESTERS WITH ANTI-INFLAMMATORY PROPERTIES PTGS1, PTGER1, PTGES2 MAPT 4043/4885TSHR 3299/4885ZAP70 4444/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.