Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | GRM6 | O15303 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.34 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.34 |
| ▸ | GRM8 | O00222 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | TLR4 | O00206 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18214762 | 0.77 | ATM (0.42) | ATMALDH1A1KDM4EALOX15GRM6 | |
| SCHEMBL12934632 | 0.75 | TSHR (0.39) | ATMALDH1A1KDM4EALOX15TLR4 | |
| SCHEMBL77511 | 0.74 | RECQL (0.55) | ATMALDH1A1KDM4ERECQLGAA | |
| SCHEMBL16614406 | 0.74 | ATM (0.39) | ATMALDH1A1KDM4EALOX15GRM6 | |
| SCHEMBL9620230 | 0.74 | ATM (0.39) | ATMALDH1A1KDM4EALOX15GRM6 | |
| SCHEMBL25025784 | 0.74 | ALOX15 (0.42) | ATMALDH1A1KDM4EALOX15GRM6 | |
| SCHEMBL6604915 | 0.74 | ATM (0.39) | ATMALDH1A1KDM4EALOX15GRM6 | |
| SCHEMBL25024421 | 0.74 | ALOX15 (0.42) | ATMALDH1A1KDM4EALOX15GRM6 | |
| SCHEMBL30233576 | 0.74 | ALOX15 (0.42) | ATMALDH1A1KDM4EALOX15GRM6 | |
| SCHEMBL14904407 | 0.73 | ATM (0.42) | ATMALDH1A1KDM4EALOX15GRM6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |