Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | GRM6 | O15303 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | TLR4 | O00206 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | GRM8 | O00222 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30777466 | 0.98 | ATM (0.41) | ATMALDH1A1KDM4EALOX15EPHX2 | |
| SCHEMBL14970367 | 0.83 | ALOX15 (0.47) | ATMALDH1A1KDM4EALOX15EPHX2 | |
| SCHEMBL26172551 | 0.82 | ATM (0.38) | ATMALDH1A1KDM4EALOX15EPHX2 | |
| SCHEMBL24939292 | 0.82 | EPHX2 (0.35) | EPHX2APLNR | |
| SCHEMBL31072096 | 0.80 | CHRNB2 (0.36) | ATMALDH1A1KDM4EALOX15EPHX2 | |
| SCHEMBL27186331 | 0.79 | GAA (0.35) | KDM4EEPHX2APLNR | |
| SCHEMBL15129467 | 0.78 | APLNR (0.33) | EPHX2APLNR | |
| SCHEMBL19198696 | 0.77 | IDO1 (0.38) | ATMEPHX2MTNR1AMTNR1B | |
| SCHEMBL12437203 | 0.77 | EPHX2 (0.59) | ATMALDH1A1KDM4EALOX15EPHX2 | |
| SCHEMBL31493448 | 0.77 | ATM (0.39) | ATMALDH1A1KDM4EALOX15MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240383863-A1 | PREPARATION METHOD FOR PYRIMIDINE-2-AMINE | INSTITUTE FOR BASIC SCIENCE (KR) | 2024-11-21 | — | — | US | disclosed |
| EP-4408530-A1 | BENZIMIDAZOLES AS MODULATORS OF IL-17 | Janssen Pharmaceutica NV (BE) | 2024-08-07 | — | — | EP | disclosed |
| EP-3356345-B1 | HETEROARYL DERIVATIVES AS SEPIAPTERIN REDUCTASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2023-11-08 | — | — | EP | disclosed |
| CN-114507244-B | Imidazo thiazole compound, pharmaceutical composition and application thereof | 广州市恒诺康医药科技有限公司 | 2023-10-27 | — | — | CN | disclosed |
| WO-2023072974-A1 | TRICYCLIC HETEROCYCLES | MERCK PATENT GMBH (DE) | 2023-05-04 | — | — | WO | disclosed |
| WO-2023049888-A1 | BENZIMIDAZOLES AS MODULATORS OF IL-17 | JANSSEN PHARMACEUTICA NV (BE) | 2023-03-30 | — | — | WO | disclosed |
| WO-2023043292-A1 | PREPARATION METHOD FOR PYRIMIDINE-2-AMINE | 기초과학연구원 | 2023-03-23 | — | — | WO | disclosed |
| WO-2023025109-A1 | TOLL-LIKE RECEPTOR INHIBITOR AND PREPARATION AND APPLICATION THEREOF | 上海维申医药有限公司 | 2023-03-02 | — | — | WO | disclosed |
| CN-114907341-A | Pyridopyrimidinone derivatives, and preparation method and application thereof | 武汉人福创新药物研发中心有限公司 | 2022-08-16 | — | — | CN | disclosed |
| WO-2022166974-A1 | PYRIDOPYRIMIDINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-08-11 | — | — | WO | disclosed |
| US-20150284384-A1 | RING-FUSED HETEROCYCLIC COMPOUND | KYOWA KIRIN CO., LTD. (JP) | 2015-10-08 | — | — | US | disclosed |
| EP-2881394-A1 | CONDENSED RING HETEROCYCLIC COMPOUND | Kyowa Hakko Kirin Co., Ltd. (JP) | 2015-06-10 | — | — | EP | disclosed |
| US-9018200-B2 | Substituted piperidinyl compounds useful as GPR119 agonists | MERCK SHARP & DOHME CORP. (US) | 2015-04-28 | — | — | US | disclosed |
| US-9000186-B2 | Ring-fused heterocyclic derivative | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2015-04-07 | — | — | US | disclosed |
| US-9000186-B2 | Ring-fused heterocyclic derivative | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2015-04-07 | — | — | US | disclosed |
| US-20140296202-A1 | SUBSTITUTED PIPERIDINYL COMPOUNDS USEFUL AS GPR119 AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2014-10-02 | — | — | US | disclosed |
| US-20140058103-A1 | Inhibitors of PI3K-Delta and Methods of Their Use and Manufacture | EXELIXIS, INC. (US) | 2014-02-27 | — | — | US | disclosed |
| US-20140038941-A1 | RING-FUSED HETEROCYCLIC DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2014-02-06 | — | — | US | disclosed |
| US-20140038941-A1 | RING-FUSED HETEROCYCLIC DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2014-02-06 | — | — | US | disclosed |
| WO-2013062838-A1 | SUBSTITUTED PIPERIDINYL COMPOUNDS USEFUL AS GPR119 AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2013-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240383863-A1 | PREPARATION METHOD FOR PYRIMIDINE-2-AMINE | NUDT1, UMPS, DPYD | ATM 1142/4885ALDH1A1 2073/4885KDM4E 2802/4885 |
| US-20140296202-A1 | SUBSTITUTED PIPERIDINYL COMPOUNDS USEFUL AS GPR119 AGONISTS | GPR119, GPR27, GPR139 | ATM 4317/4885ALDH1A1 1340/4885KDM4E 3884/4885 |
| US-20140058103-A1 | Inhibitors of PI3K-Delta and Methods of Their Use and Manufacture | PIK3CD, PIK3CA, PIK3R5 | ATM 975/4885ALDH1A1 3321/4885KDM4E 2378/4885 |
| US-20140038941-A1 | RING-FUSED HETEROCYCLIC DERIVATIVE | CACNA1E, SLC8A1, CALCR | ATM 4632/4885ALDH1A1 3112/4885KDM4E 3779/4885 |
| US-20150284384-A1 | RING-FUSED HETEROCYCLIC COMPOUND | TRPV1, TRPV2, TRPV3 | ATM 4786/4885ALDH1A1 4202/4885KDM4E 3471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.