Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2402616 | 0.79 | KMT2A (0.38) | KMT2AMEN1ATMALDH1A1THRB | |
| SCHEMBL2400757 | 0.78 | KMT2A (0.47) | KMT2AMEN1ATMPOLBALDH1A1 | |
| SCHEMBL2404636 | 0.75 | ATM (0.43) | KMT2AATMALDH1A1KDM4ECNR1 | |
| SCHEMBL6409831 | 0.74 | ATM (0.55) | KMT2AATMPOLBALDH1A1KDM4E | |
| SCHEMBL6411053 | 0.72 | KMT2A (0.46) | KMT2AMEN1ATMPOLBALDH1A1 | |
| SCHEMBL2403568 | 0.71 | NAMPT (0.42) | KMT2AMEN1ATMALDH1A1CNR1 | |
| SCHEMBL2400090 | 0.70 | CACNA1G (0.46) | MAPTGAASMN1; SMN2ADRB2 | |
| SCHEMBL2400043 | 0.69 | USP2 (0.42) | KMT2AMEN1ATMALDH1A1CNR1 | |
| SCHEMBL2403236 | 0.68 | ALDH1A1 (0.40) | ATMPOLBALDH1A1TSHRNPSR1 | |
| SCHEMBL2400718 | 0.68 | DRD4 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048890-B2 | Analgesics; neuropathic pain; headaches; muscle relaxants; incontence; tinnitus; diarrhea; antiarrhythmia agents; antiischemic agents; antiinflammatory agents; antiulcer agents; antidepressants; antiepileptic agents | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |