Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22627935 | 0.90 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2AHTTPPARG | |
| SCHEMBL22628294 | 0.88 | RXFP1 (0.57) | GRIN1GRIN2BALDH1A1MEN1KMT2A | |
| SCHEMBL22627651 | 0.86 | KMT2A (0.56) | GRIN1GRIN2BALDH1A1MEN1KMT2A | |
| SCHEMBL20999395 | 0.84 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2AHTTPPARG | |
| SCHEMBL22627776 | 0.83 | GRIN1 (0.43) | GRIN1GRIN2BALDH1A1MEN1KMT2A | |
| SCHEMBL22956480 | 0.83 | ATF4 (0.44) | ALDH1A1PPARGSMN1; SMN2 | |
| SCHEMBL22628080 | 0.83 | ALDH1A1 (0.47) | GRIN1GRIN2BALDH1A1MEN1KMT2A | |
| SCHEMBL22669601 | 0.82 | SMN1; SMN2 (0.46) | GRIN1GRIN2BALDH1A1MEN1KMT2A | |
| SCHEMBL22956244 | 0.82 | GRM4 (0.48) | GRIN1GRIN2BALDH1A1MEN1KMT2A | |
| SCHEMBL22627721 | 0.82 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2ASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |