Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31011039 | 1.00 | MAPT (0.50) | MAPTKMT2ANPC1RAB9AKDM4E | |
| SCHEMBL10947088 | 0.89 | KMT2A (0.50) | MAPTKMT2ANPC1RAB9AKDM4E | |
| SCHEMBL31483496 | 0.86 | MAPT (0.49) | MAPTKMT2ANPC1RAB9AKDM4E | |
| SCHEMBL6824033 | 0.86 | MAPT (0.49) | MAPTKMT2ANPC1RAB9AKDM4E | |
| SCHEMBL17204642 | 0.85 | ALDH1A1 (0.47) | MAPTKMT2ARAB9AKDM4EMEN1 | |
| SCHEMBL16396278 | 0.83 | ALDH1A1 (0.51) | MAPTKMT2ANPC1RAB9AKDM4E | |
| SCHEMBL3680399 | 0.83 | MCL1 (0.50) | MAPTKMT2ANPC1RAB9AKDM4E | |
| SCHEMBL1547808 | 0.81 | MAPT (0.44) | MAPTKMT2ANPC1RAB9AKDM4E | |
| SCHEMBL2895958 | 0.80 | GPR35 (0.58) | KMT2ANPC1MEN1SMN1; SMN2NPSR1 | |
| SCHEMBL25946765 | 0.80 | MAPT (0.46) | MAPTKMT2ANPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125376-A1 | FUSED BICYCLIC HETEROARYL AMIDE COMPOUND AS PROTEIN AGGREGATION INHIBITOR | 上海京新生物医药有限公司 | 2023-07-06 | — | — | WO | disclosed |