Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 15/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22956670 | 0.94 | ALDH1A1 (0.45) | ATF4ALDH1A1TDP1EGLN2EGLN1 | |
| SCHEMBL22956472 | 0.88 | ATF4 (0.39) | ATF4ALDH1A1TDP1 | |
| SCHEMBL22956512 | 0.88 | EGLN2 (0.40) | ATF4ALDH1A1EGLN2EGLN1 | |
| SCHEMBL25804558 | 0.85 | ALDH1A1 (0.42) | ATF4ALDH1A1TDP1 | |
| SCHEMBL25821098 | 0.85 | ATF4 (0.42) | ATF4ALDH1A1EGLN2EGLN1 | |
| SCHEMBL22956290 | 0.85 | ATF4 (0.42) | ATF4ALDH1A1EGLN2EGLN1 | |
| SCHEMBL22627982 | 0.85 | ATF4 (0.43) | ATF4ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL22956580 | 0.85 | ATF4 (0.40) | ATF4ALDH1A1EGLN2EGLN1 | |
| SCHEMBL20999623 | 0.84 | ALDH1A1 (0.47) | ATF4ALDH1A1TDP1 | |
| SCHEMBL22627706 | 0.84 | ATF4 (0.42) | ATF4ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |