Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 11/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 11/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12077888 | 0.89 | LPL (0.37) | LPLLIPGPRMT5WDR77CA1 | |
| SCHEMBL12077092 | 0.83 | NPC1 (0.34) | LPLLIPGPRMT5WDR77CA1 | |
| SCHEMBL12077094 | 0.83 | NPC1 (0.34) | LPLLIPGPRMT5WDR77CA1 | |
| SCHEMBL274197 | 0.78 | ROCK1 (0.43) | LPLLIPGPRMT5WDR77CA9 | |
| SCHEMBL4853578 | 0.77 | ACVR1 (0.49) | LPLLIPGCSF1RROCK1 | |
| SCHEMBL30720809 | 0.76 | PARP10 (0.54) | — | |
| SCHEMBL12078315 | 0.76 | CDC7 (0.39) | LPLLIPGPRMT5WDR77CA1 | |
| SCHEMBL1636716 | 0.76 | PARP10 (0.54) | — | |
| SCHEMBL30926385 | 0.76 | CDC7 (0.39) | LPLLIPGPRMT5WDR77CA1 | |
| SCHEMBL29609304 | 0.75 | CLK4 (0.44) | LPLLIPGPRMT5WDR77CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3313828-B1 | METALLO-BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-07-12 | — | — | EP | disclosed |