Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.67 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | APEX1 | P27695 | 1/20 | 0.63 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.62 |
| ▸ | PPARG | P37231 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.51 |
| ▸ | PRNP | P04156 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13401405 | 0.86 | KDM4E (0.73) | KDM4EALDH1A1RXFP1HPGDTHRB | |
| SCHEMBL25811504 | 0.84 | HCRTR1 (0.74) | KDM4EALDH1A1HPGDPOLBMAPT | |
| SCHEMBL29037343 | 0.83 | PPARG (0.58) | KDM4EALDH1A1RXFP1HPGDTHRB | |
| SCHEMBL5816059 | 0.82 | KDM4E (0.60) | KDM4EALDH1A1RXFP1HPGDTHRB | |
| SCHEMBL10146001 | 0.81 | KDM4E (0.60) | KDM4EALDH1A1RXFP1HPGDTHRB | |
| SCHEMBL9581504 | 0.81 | KDM4E (0.60) | KDM4EALDH1A1RXFP1HPGDTHRB | |
| SCHEMBL8529584 | 0.81 | PTPN5 (0.62) | KDM4EALDH1A1RXFP1HPGDTHRB | |
| SCHEMBL1586810 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1RXFP1HPGDTHRB | |
| SCHEMBL5881790 | 0.80 | PTPN5 (0.58) | KDM4EALDH1A1RXFP1HPGDTHRB | |
| SCHEMBL5881620 | 0.79 | PTPN5 (0.57) | KDM4EALDH1A1RXFP1HPGDTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230218573-A1 | INDOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | GALYAN BIO INC (US) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230218573-A1 | INDOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | HTT, HYPK, PARK7 | KDM4E 1465/4885ALDH1A1 4430/4885RXFP1 4033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.