Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14722834 | 0.77 | NPFFR1 (0.50) | TSHRALDH1A1CYP2D6CYP2C19KMT2A | |
| SCHEMBL8695092 | 0.74 | KDM4E (0.52) | USP30KMT2APKMKDM4EMEN1 | |
| SCHEMBL27273673 | 0.73 | NR1H2 (0.41) | USP30TSHRALDH1A1HSD17B10TDP1 | |
| SCHEMBL20769626 | 0.73 | MEN1 (0.49) | ALDH1A1CYP2C19KMT2AKDM4EMAPT | |
| SCHEMBL3296151 | 0.73 | OPRL1 (0.42) | TSHRALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL28379744 | 0.73 | CTSD (0.34) | USP30TSHR | |
| SCHEMBL25970161 | 0.73 | PDK2 (0.43) | USP30KMT2APKMKDM4EMEN1 | |
| SCHEMBL22615389 | 0.72 | CYP2D6 (0.42) | TSHRALDH1A1HSD17B10TDP1CYP1A2 | |
| SCHEMBL25737059 | 0.72 | F2 (0.44) | TSHRALDH1A1CYP1A2CYP2C19KMT2A | |
| SCHEMBL27121468 | 0.72 | KMT2A (0.39) | USP30TSHRALDH1A1HSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675847-B1 | SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | H LUNDBECK AS (DK) | 2023-07-12 | — | — | EP | disclosed |