Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.33 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.33 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.33 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2577948 | 1.00 | HTR2A (0.36) | HTR2AHTR2CHTR2BKDM1AMAOB | |
| SCHEMBL29330391 | 0.83 | KDM1A (0.38) | HTR2AHTR2CHTR2BKDM1AMAOB | |
| SCHEMBL2708172 | 0.83 | KDM1A (0.38) | HTR2AHTR2CHTR2BKDM1AMAOB | |
| SCHEMBL20119393 | 0.75 | KDM1A (0.42) | HTR2AHTR2CKDM1ACHRNB2CHRNB4 | |
| SCHEMBL24365538 | 0.74 | CHRNB2 (0.33) | HTR2AHTR2CHTR2BKDM1AMAOB | |
| SCHEMBL29081504 | 0.74 | CHRNB2 (0.33) | HTR2AHTR2CHTR2BKDM1AMAOB | |
| SCHEMBL29081502 | 0.74 | CHRNB2 (0.33) | HTR2AHTR2CHTR2BKDM1AMAOB | |
| SCHEMBL19580516 | 0.72 | HTR2C (0.42) | HTR2CKDM1APRCP | |
| SCHEMBL6140740 | 0.72 | PRCP (0.60) | PRCPDDB1CRBN | |
| SCHEMBL172513 | 0.72 | KDM1A (0.45) | HTR2AHTR2CHTR2BKDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953158-B1 | BICYCLIC CINNAMIDE COMPOUND | EISAI R&D MAN CO LTD (JP) | 2012-09-12 | — | — | EP | disclosed |
| US-8048878-B2 | Two cyclic cinnamide compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-11-01 | — | — | US | disclosed |
| US-20090181945-A1 | TWO CYCLIC CINNAMIDE COMPOUND | KIMURA TEIJI | 2009-07-16 | — | — | US | disclosed |
| EP-1953158-A1 | BICYCLIC CINNAMIDE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2008-08-06 | — | — | EP | disclosed |
| US-20070117839-A1 | Two cyclic cinnamide compound | EISAI R&D MANAGEMENT CO., LTD. | 2007-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181945-A1 | TWO CYCLIC CINNAMIDE COMPOUND | APP, BACE1, PSEN1 | HTR2A 884/4885HTR2C 2035/4885HTR2B 1336/4885 |
| US-20070117839-A1 | Two cyclic cinnamide compound | APP, BACE1, PSEN1 | HTR2A 884/4885HTR2C 2035/4885HTR2B 1336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.