Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | NT5E | P21589 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30971512 | 0.80 | TRPV1 (0.40) | PDE4BLMNATRPV1 | |
| SCHEMBL3772488 | 0.80 | TRPV1 (0.40) | PDE4BLMNATRPV1 | |
| SCHEMBL29685815 | 0.80 | TRPV4 (0.32) | TRPV4P2RX7NT5EPDE4BMEN1 | |
| SCHEMBL20771377 | 0.78 | TRIM24 (0.41) | TRPV4P2RX7NT5EPDE4BMEN1 | |
| SCHEMBL1085828 | 0.78 | ALDH1A1 (0.41) | TRPV4P2RX7NT5EPDE4BMEN1 | |
| SCHEMBL125558 | 0.78 | PIK3CD (0.35) | TRPV4P2RX7LMNA | |
| SCHEMBL30695180 | 0.78 | TRIM24 (0.41) | TRPV4P2RX7NT5EPDE4BMEN1 | |
| SCHEMBL3779145 | 0.74 | HCRTR1 (0.33) | P2RX7PDE4BMEN1KMT2ALMNA | |
| SCHEMBL30971780 | 0.74 | PDE4B (0.39) | NT5EPDE4BMEN1KMT2ALMNA | |
| SCHEMBL1473840 | 0.74 | ALDH1A1 (0.46) | PDE4BMEN1KMT2ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675847-B1 | SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | H LUNDBECK AS (DK) | 2023-07-12 | — | — | EP | disclosed |