Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.45 |
| ▸ | ATF4 | P18848 | 9/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22627559 | 0.94 | ATF4 (0.41) | TRPV1ATF4TDP1GCGREPHX2 | |
| SCHEMBL22627577 | 0.90 | KMT2A (0.43) | TRPV1ATF4TDP1L3MBTL1 | |
| SCHEMBL25798242 | 0.89 | TRPV1 (0.57) | TRPV1ATF4GCGRL3MBTL1 | |
| SCHEMBL22627742 | 0.89 | TDP1 (0.51) | TRPV1TDP1GCGREPHX2L3MBTL1 | |
| SCHEMBL22956410 | 0.88 | TDP1 (0.39) | ATF4TDP1L3MBTL1 | |
| SCHEMBL25813464 | 0.88 | ATF4 (0.41) | TRPV1ATF4TDP1L3MBTL1 | |
| SCHEMBL22627852 | 0.87 | TRPV1 (0.43) | TRPV1TDP1EPHX2 | |
| SCHEMBL22627974 | 0.87 | TDP1 (0.51) | TRPV1ATF4TDP1EPHX2 | |
| SCHEMBL22956229 | 0.87 | TDP1 (0.42) | TRPV1ATF4TDP1L3MBTL1 | |
| SCHEMBL25796793 | 0.87 | TDP1 (0.53) | TRPV1ATF4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |