Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ATF4 | P18848 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22627974 | 0.98 | TDP1 (0.51) | TDP1TRPV1KMT2APOLBATF4 | |
| SCHEMBL22628253 | 0.88 | TRPV1 (0.42) | TDP1TRPV1ATF4 | |
| SCHEMBL22627559 | 0.88 | ATF4 (0.41) | TDP1TRPV1ATF4 | |
| SCHEMBL25797022 | 0.87 | TDP1 (0.53) | TDP1KMT2APOLBATF4MEN1 | |
| SCHEMBL25812812 | 0.87 | TRPV1 (0.45) | TDP1TRPV1ATF4 | |
| SCHEMBL24116707 | 0.83 | GRIN1 (0.41) | ATF4 | |
| SCHEMBL22627948 | 0.82 | MEN1 (0.46) | TDP1TRPV1KMT2AATF4MEN1 | |
| SCHEMBL22437091 | 0.82 | ATF4 (0.54) | ATF4 | |
| SCHEMBL19556276 | 0.82 | ATF4 (0.61) | ATF4 | |
| SCHEMBL22627981 | 0.80 | TRPV1 (0.46) | TDP1TRPV1KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |