SCHEMBL25815514

SCHEMBL25815514

Cc1ccc(C(=O)Nc2ccc(CCc3ccc(-c4ccc(C)cc4)cc3)cc2)cc1

nearest known ligand 0.71

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 0.71
RAB9A P51151 5/20 0.71
CCR5 P51681 2/20 0.61
MAPT P10636 2/20 0.60
SMN1; SMN2 Q16637 1/20 0.60
NR1H4 Q96RI1 2/20 0.57
ENPP1 P22413 1/20 0.56
PTPN1 P18031 4/20 0.56
MEN1 O00255 1/20 0.55
KMT2A Q03164 1/20 0.55
TRPV1 Q8NER1 2/20 0.55
KDM4E B2RXH2 1/20 0.55
ALDH1A1 P00352 1/20 0.55
NAMPT P43490 1/20 0.53
KIF11 P52732 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25970267 0.90 RAB9A (0.88) NPC1RAB9AMAPTSMN1; SMN2PTPN1
SCHEMBL25491824 0.90 RAB9A (0.88) NPC1RAB9AMAPTSMN1; SMN2PTPN1
SCHEMBL15214314 0.90 RAB9A (0.88) NPC1RAB9AMAPTSMN1; SMN2PTPN1
SCHEMBL17066707 0.90 RAB9A (0.88) NPC1RAB9AMAPTSMN1; SMN2PTPN1
SCHEMBL8867477 0.87 NPC1 (0.71) NPC1RAB9ACCR5MAPTSMN1; SMN2
SCHEMBL8867481 0.87 NPC1 (0.71) NPC1RAB9ACCR5MAPTSMN1; SMN2
SCHEMBL8361574 0.87 NPC1 (0.71) NPC1RAB9ACCR5MAPTSMN1; SMN2
SCHEMBL8868824 0.87 NPC1 (0.71) NPC1RAB9ACCR5MAPTSMN1; SMN2
SCHEMBL24935348 0.84 NPC1 (0.67) NPC1RAB9ACCR5MAPTSMN1; SMN2
SCHEMBL17664553 0.84 NR1H4 (0.74) NPC1RAB9ACCR5MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4213290-A2 SEPARATOR AND APPLICATION THEREOF Microcosm Technology Co., Ltd. (TW) 2023-07-19 EP disclosed