SCHEMBL25815965

SCHEMBL25815965

CC(C)(C)[Si](C)(C)OCc1nc(Cl)ncc1F

nearest known ligand 0.34

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
POLB P06746 2/20 0.31
CASP6 P55212 1/20 0.31
KMT2A Q03164 1/20 0.31
GAA P10253 1/20 0.30
CA12 O43570 1/20 0.30
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
CA9 Q16790 1/20 0.30
CA14 Q9ULX7 1/20 0.30
LMNA P02545 1/20 0.30
RAB9A P51151 1/20 0.30
ATM Q13315 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24922312 0.77 ALDH1A1 (0.39) ALDH1A1L3MBTL1SMN1; SMN2POLBCASP6
SCHEMBL20501232 0.75 CA12 (0.33) CA12CA1CA2CA9CA14
SCHEMBL24676031 0.74 KDM4E (0.32)
SCHEMBL25815977 0.74
SCHEMBL19219151 0.74 LMNA (0.31) L3MBTL1POLBCA12CA1CA2
SCHEMBL25815755 0.73
SCHEMBL29754856 0.73
SCHEMBL24676592 0.73
SCHEMBL21311731 0.72 MAPKAPK5 (0.34)
SCHEMBL1999624 0.72 ALDH1A1 (0.46) ALDH1A1L3MBTL1KMT2ACA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023125182-A1 PROPIONIC ACID DERIVATIVE AND MEDICAL USE THEREOF 海思科医药集团股份有限公司 2023-07-06 WO disclosed