Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25801914 | 0.86 | MRGPRX4 (0.46) | MRGPRX4KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL20999307 | 0.85 | MRGPRX4 (0.39) | MRGPRX4KMT2AMEN1SMYD3ALDH1A1 | |
| SCHEMBL22956306 | 0.82 | ADORA3 (0.42) | MRGPRX4KMT2AMEN1HPGDCYP1A2 | |
| SCHEMBL22956371 | 0.79 | MEN1 (0.39) | MRGPRX4KMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL22628300 | 0.79 | KMT2A (0.49) | MRGPRX4KMT2AMEN1SMYD3CTNNB1 | |
| SCHEMBL22627759 | 0.79 | KIT (0.47) | MRGPRX4 | |
| SCHEMBL20999368 | 0.79 | MRGPRX4 (0.35) | MRGPRX4KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL22627932 | 0.78 | BACE1 (0.35) | MRGPRX4KMT2AMEN1SMYD3ALDH1A1 | |
| SCHEMBL22956329 | 0.78 | GCGR (0.37) | MRGPRX4KMT2ANPC1RAB9A | |
| SCHEMBL25798610 | 0.78 | SMN1; SMN2 (0.34) | MRGPRX4KMT2AMEN1SMYD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |