Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25816162 | 0.86 | MRGPRX4 (0.43) | MRGPRX4KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL25815642 | 0.81 | ALDH1A1 (0.50) | MRGPRX4KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL20999307 | 0.80 | MRGPRX4 (0.39) | MRGPRX4KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL22956306 | 0.78 | ADORA3 (0.42) | MRGPRX4KMT2AMEN1MAPTRAB9A | |
| SCHEMBL19569741 | 0.77 | MRGPRX4 (0.46) | MRGPRX4KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL22956371 | 0.77 | MEN1 (0.39) | MRGPRX4KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL20974037 | 0.77 | ATF4 (0.56) | MRGPRX4ALDH1A1RAB9ANPC1HPGD | |
| SCHEMBL19555277 | 0.76 | MRGPRX4 (0.59) | MRGPRX4MAPTALDH1A1KDM4EGAA | |
| SCHEMBL24116726 | 0.76 | RAB9A (0.42) | MRGPRX4KMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL19555348 | 0.75 | MRGPRX4 (0.54) | MRGPRX4KMT2AMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |