Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.45 |
| ▸ | IKZF3 | Q9UKT9 | 7/20 | 0.45 |
| ▸ | AR | P10275 | 3/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25816414 | 0.83 | CRBN (0.48) | CRBNDDB1IKZF3ARCDK9 | |
| SCHEMBL25816349 | 0.80 | ALDH1A1 (0.36) | — | |
| SCHEMBL24421574 | 0.79 | CRBN (0.44) | CRBNARCDK9BTKEGFR | |
| SCHEMBL29597261 | 0.79 | CRBN (0.54) | CRBNDDB1IKZF3ARCDK9 | |
| SCHEMBL23134695 | 0.79 | CRBN (0.58) | CRBNDDB1IKZF3ARCDK9 | |
| SCHEMBL24918212 | 0.78 | CRBN (0.41) | CRBNDDB1IKZF3ARCDK9 | |
| SCHEMBL24918214 | 0.78 | CRBN (0.47) | CRBNDDB1IKZF3ARBTK | |
| SCHEMBL22661322 | 0.77 | CRBN (0.55) | CRBNDDB1IKZF3ARCDK9 | |
| SCHEMBL22661395 | 0.77 | CRBN (0.55) | CRBNDDB1IKZF3ARCDK9 | |
| SCHEMBL23134596 | 0.76 | CRBN (0.58) | CRBNDDB1IKZF3ARCDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129506-A1 | POTENT AND SELECTIVE SMARCA2 DEGRADING CHIMERIC MOLECULES AS CANCER THERAPEUTICS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-07-06 | — | — | WO | disclosed |