Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23952038 | 0.82 | NLRP3 (0.74) | NLRP3DHODH | |
| SCHEMBL25817722 | 0.81 | NLRP3 (0.51) | NLRP3DHODH | |
| SCHEMBL25816523 | 0.77 | NLRP3 (0.51) | NLRP3 | |
| SCHEMBL23952378 | 0.75 | NLRP3 (0.70) | NLRP3DHODH | |
| SCHEMBL23952189 | 0.72 | NLRP3 (0.78) | NLRP3DHODH | |
| SCHEMBL30249411 | 0.72 | NLRP3 (0.78) | NLRP3DHODH | |
| SCHEMBL23952424 | 0.72 | NLRP3 (0.78) | NLRP3DHODH | |
| SCHEMBL30061659 | 0.71 | NLRP3 (0.76) | NLRP3DHODH | |
| SCHEMBL23952035 | 0.71 | NLRP3 (0.76) | NLRP3DHODH | |
| SCHEMBL23952062 | 0.71 | NLRP3 (0.76) | NLRP3DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183248-A1 | PYRROLO[1,2-D][1,2,4]TRIAZINE-2-YL-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183248-A1 | PYRROLO[1,2-D][1,2,4]TRIAZINE-2-YL-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | NLRP3, NLRP1, IL1B | NLRP3 1/4885DHODH 1822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.