Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23952019 | 0.91 | NLRP3 (0.43) | NLRP3TP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL23952023 | 0.88 | NLRP3 (0.43) | NLRP3TP53SMN1; SMN2MAPTPOLB | |
| SCHEMBL23952013 | 0.88 | KDM4E (0.46) | NLRP3SMN1; SMN2KDM4EMEN1ALDH1A1 | |
| SCHEMBL25816710 | 0.87 | NLRP3 (0.51) | NLRP3TP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL25816750 | 0.80 | NLRP3 (0.38) | NLRP3TP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL25816762 | 0.77 | NLRP3 (0.36) | NLRP3TP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL23952067 | 0.76 | NLRP3 (0.54) | NLRP3TP53KMT2AMAPTTHRB | |
| SCHEMBL25819165 | 0.75 | NLRP3 (0.40) | NLRP3NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL23952567 | 0.74 | NLRP3 (0.50) | NLRP3SMN1; SMN2KDM4EMEN1ALDH1A1 | |
| SCHEMBL23952009 | 0.74 | CYP2C19 (0.42) | NLRP3SMN1; SMN2KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183248-A1 | PYRROLO[1,2-D][1,2,4]TRIAZINE-2-YL-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183248-A1 | PYRROLO[1,2-D][1,2,4]TRIAZINE-2-YL-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | NLRP3, NLRP1, IL1B | NLRP3 1/4885TP53 2459/4885SMN1; SMN2 4513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.