Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 8/20 | 0.47 |
| ▸ | NPC1 | O15118 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ESRRA | P11474 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25818717 | 0.92 | KDM4E (0.55) | KDM4ELMNAALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL15233270 | 0.88 | KDM4E (0.58) | KDM4ELMNAALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL862261 | 0.84 | KDM4E (0.62) | KDM4ELMNAALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL13916682 | 0.81 | KDM4E (0.69) | KDM4ELMNAALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL13916685 | 0.79 | KDM4E (0.67) | KDM4ELMNAALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL17300601 | 0.79 | KDM4E (0.40) | KDM4ELMNAALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL2267059 | 0.79 | LMNA (0.49) | KDM4ELMNAALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL17561697 | 0.77 | KDM4E (0.55) | KDM4ELMNAALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL10151106 | 0.74 | KDM4E (0.51) | KDM4ELMNAALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL16103838 | 0.74 | LMNA (0.51) | KDM4ELMNAALDH1A1CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023133217-A1 | 2-(INDAZOL-5-YL)-6-(PIPERIDIN-4-YL)-1,7-NAPHTHYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR SPLICING NUCLEIC ACIDS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES | REMIX THERAPEUTICS INC. (US) | 2023-07-13 | — | — | WO | disclosed |