Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13916685 | 0.91 | KDM4E (0.67) | KDM4EALDH1A1LMNASMN1; SMN2GLA | |
| SCHEMBL13916682 | 0.88 | KDM4E (0.69) | KDM4EALDH1A1LMNASMN1; SMN2GLA | |
| SCHEMBL17561693 | 0.84 | KDM4E (0.55) | KDM4EALDH1A1LMNASMN1; SMN2GLA | |
| SCHEMBL25818717 | 0.84 | KDM4E (0.55) | KDM4EALDH1A1LMNASMN1; SMN2GLA | |
| SCHEMBL25818716 | 0.84 | KDM4E (0.55) | KDM4EALDH1A1LMNASMN1; SMN2GLA | |
| SCHEMBL17561697 | 0.84 | KDM4E (0.55) | KDM4EALDH1A1LMNASMN1; SMN2GLA | |
| SCHEMBL10151106 | 0.81 | KDM4E (0.51) | KDM4EALDH1A1LMNASMN1; SMN2GLA | |
| SCHEMBL16103838 | 0.81 | LMNA (0.51) | KDM4EALDH1A1LMNASMN1; SMN2GLA | |
| SCHEMBL3967634 | 0.78 | KDM4E (0.56) | KDM4EALDH1A1LMNASMN1; SMN2GLA | |
| SCHEMBL15233270 | 0.78 | KDM4E (0.58) | KDM4EALDH1A1LMNASMN1; SMN2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11040966-B2 | Benzimidazole-proline derivatives | IDORSIA PHARMACEUTICALS LTD (CH) | 2021-06-22 | — | — | US | disclosed |
| US-20190263797-A1 | BENZIMIDAZOLE-PROLINE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-08-29 | — | — | US | disclosed |
| US-20170305897-A1 | BENZIMIDAZOLE-PROLINE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2017-10-26 | — | — | US | disclosed |
| US-20170305897-A1 | BENZIMIDAZOLE-PROLINE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2017-10-26 | — | — | US | disclosed |
| US-9732075-B2 | Benzimidazole-proline derivatives | IDORSIA PHARMACEUTICALS LTD (CH) | 2017-08-15 | — | — | US | disclosed |
| US-9732075-B2 | Benzimidazole-proline derivatives | IDORSIA PHARMACEUTICALS LTD (CH) | 2017-08-15 | — | — | US | disclosed |
| US-20160372675-A1 | MACROMOLECULAR COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2016-12-22 | — | — | US | disclosed |
| US-9472763-B2 | Macromolecular compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2016-10-18 | — | — | US | disclosed |
| US-9428501-B2 | Bicyclic nitrogen-containing aromatic heterocyclic amide compound | ASTELLAS PHARMA INC. (JP) | 2016-08-30 | — | — | US | disclosed |
| US-20160152639-A1 | POLYMERIC COMPOUND AND ELECTRONIC ELEMENT | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2016-06-02 | — | — | US | disclosed |
| US-8524756-B2 | Compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2013-09-03 | — | — | US | disclosed |
| US-20120217448-A1 | MACROMOLECULAR COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-08-30 | — | — | US | disclosed |
| US-20120205596-A1 | MACROMOLECULAR COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-08-16 | — | — | US | disclosed |
| US-20120205641-A1 | PHOTOVOLTAIC CELL | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-08-16 | — | — | US | disclosed |
| US-20120205644-A1 | PHOTOVOLTAIC CELL | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-08-16 | — | — | US | disclosed |
| US-20120205593-A1 | POLYMERIC COMPOUND AND ELECTRONIC ELEMENT | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-08-16 | — | — | US | disclosed |
| US-8142908-B2 | Polymer light-emitting material comprising a conjugated polymer and compound exhibiting light emission from the triplet excited state and polymer light-emitting device using the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-03-27 | — | — | US | disclosed |
| US-20120008068-A1 | POLYMER COMPOUND AND POLYMER LIGHT-EMITTING DEVICE USING THE SAME | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-01-12 | — | — | US | disclosed |
| US-20070051922-A1 | Polymer light-emitting material and polymer light-emitting device | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2007-03-08 | — | — | US | disclosed |
| US-20070040164-A1 | Polymer complex compound and polymer light emitting device using the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11040966-B2 | Benzimidazole-proline derivatives | HCRTR1, HCRTR2, NPY1R | KDM4E 2320/4885ALDH1A1 604/4885LMNA 2613/4885 |
| US-20160372675-A1 | MACROMOLECULAR COMPOUND | EXOSC4, TRPC6, MRPS22 | KDM4E 2826/4885ALDH1A1 3653/4885LMNA 3835/4885 |
| US-20120205593-A1 | POLYMERIC COMPOUND AND ELECTRONIC ELEMENT | ARPC2, AXIN2, EMC2 | KDM4E 1757/4885ALDH1A1 1268/4885LMNA 3141/4885 |
| US-20120205596-A1 | MACROMOLECULAR COMPOUND | EXOSC4, TRPC6, MRPS22 | KDM4E 2826/4885ALDH1A1 3653/4885LMNA 3835/4885 |
| US-20190263797-A1 | BENZIMIDAZOLE-PROLINE DERIVATIVES | HCRTR1, HCRTR2, NPY1R | KDM4E 2320/4885ALDH1A1 604/4885LMNA 2613/4885 |
| US-20160152639-A1 | POLYMERIC COMPOUND AND ELECTRONIC ELEMENT | ARPC2, AXIN2, EMC2 | KDM4E 1742/4885ALDH1A1 1314/4885LMNA 3111/4885 |
| US-20170305897-A1 | BENZIMIDAZOLE-PROLINE DERIVATIVES | HCRTR1, HCRTR2, NPY1R | KDM4E 2320/4885ALDH1A1 604/4885LMNA 2613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.