Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | CCNK | O75909 | 4/20 | 0.38 |
| ▸ | CDK9 | P50750 | 4/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31270725 | 1.00 | KCNH3 (0.41) | KCNH3KCNH2ATMATRADORA2A | |
| SCHEMBL25262335 | 0.81 | KCNH2 (0.37) | KCNH3KCNH2ATMATRADORA2A | |
| SCHEMBL31025949 | 0.81 | KCNH2 (0.37) | KCNH3KCNH2ATMATRADORA2A | |
| SCHEMBL4319972 | 0.80 | KCNH2 (0.47) | KCNH3KCNH2ATMATRCSF1R | |
| SCHEMBL29030594 | 0.80 | GRIN2B (0.44) | KCNH2ADORA2AADORA2B | |
| SCHEMBL21566302 | 0.74 | PDE7A (0.40) | ADORA2AADORA2BPDE4BPDE7APDE4A | |
| SCHEMBL31270846 | 0.74 | KDM4E (0.48) | ADORA2AADORA2B | |
| SCHEMBL25255284 | 0.74 | KDM4E (0.48) | ADORA2AADORA2B | |
| SCHEMBL25301684 | 0.74 | NPC1 (0.38) | KCNH2ATMATRADORA2AADORA2B | |
| SCHEMBL25818350 | 0.74 | GRIN2B (0.40) | ADORA2AADORA2BVNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125121-A1 | TRICYCLIC COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2023-07-06 | — | — | WO | disclosed |