Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 6/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | USP2 | O75604 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | CASP1 | P29466 | 4/20 | 0.38 |
| ▸ | CASP7 | P55210 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | HBB | P68871 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 5/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969743 | 0.88 | AXL (0.42) | AXLLTA4HJAK2HDAC1HDAC6 | |
| SCHEMBL3973562 | 0.87 | AXL (0.42) | AXLLTA4HJAK2HDAC1HDAC6 | |
| SCHEMBL3967336 | 0.87 | SRC (0.44) | AXLJAK2HDAC1HDAC6JAK3 | |
| SCHEMBL3971087 | 0.86 | AXL (0.41) | AXLLTA4HJAK2HDAC1HDAC6 | |
| SCHEMBL3965200 | 0.85 | AXL (0.41) | AXLCDK1KDRLTA4HJAK2 | |
| SCHEMBL3967433 | 0.85 | AXL (0.44) | AXLJAK2HDAC1HDAC6JAK3 | |
| SCHEMBL3965488 | 0.85 | CHRNA1 (0.41) | AXLCDK1KDRLTA4HJAK2 | |
| SCHEMBL3967985 | 0.84 | AXL (0.39) | AXLLTA4HJAK2HDAC1HDAC6 | |
| SCHEMBL3966066 | 0.83 | AXL (0.41) | AXLKDRJAK2HDAC1HDAC6 | |
| SCHEMBL3967352 | 0.83 | CHEK1 (0.39) | AXLCDK1KDRLTA4HJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | claimed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |