SCHEMBL25822375

SCHEMBL25822375

Nc1c(Br)cc(Br)c2c(CCF)cccc12

nearest known ligand 0.46

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HKDC1 Q2TB90 1/20 0.46
CASP6 P55212 1/20 0.38
CTSB P07858 1/20 0.37
TAAR1 Q96RJ0 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23409303 0.75 HKDC1 (0.58) HKDC1CASP6CTSB
SCHEMBL29940073 0.74 HKDC1 (0.53) HKDC1CASP6CTSB
SCHEMBL23043391 0.74 HKDC1 (0.53) HKDC1CASP6CTSB
SCHEMBL29418744 0.70 HKDC1 (0.58) HKDC1CASP6CTSB
SCHEMBL23043385 0.70 HKDC1 (0.58) HKDC1CASP6CTSB
SCHEMBL4880191 0.68 CTSB (0.55) HKDC1CASP6CTSB
SCHEMBL30064912 0.68 CTSB (0.55) HKDC1CASP6CTSB
SCHEMBL26197128 0.68 TAAR1 (0.41) TAAR1
SCHEMBL25822334 0.68 HTR2A (0.34) TAAR1
SCHEMBL30259983 0.67 HKDC1 (0.49) HKDC1CASP6CTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023125989-A1 QUINAZOLINE COMPOUND AND APPLICATION THEREOF 上海医药集团股份有限公司 2023-07-06 WO disclosed