Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18949738 | 0.83 | TSHR (0.49) | CYP2A6CYP3A4CYP2E1SMN1; SMN2GRM1 | |
| SCHEMBL31755975 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTRAB9ANPC1LMNA | |
| SCHEMBL16019532 | 0.78 | GRM1 (0.42) | CYP2A6CYP3A4CYP2E1SMN1; SMN2GRM1 | |
| SCHEMBL2689365 | 0.76 | SMN1; SMN2 (0.41) | CYP2A6CYP3A4CYP2E1SMN1; SMN2GRM1 | |
| SCHEMBL13740923 | 0.73 | CYP2A6 (0.44) | CYP2A6CYP3A4CYP2E1SMN1; SMN2GRM1 | |
| SCHEMBL9025915 | 0.73 | CYP2A6 (0.44) | CYP2A6CYP3A4CYP2E1GRM1ALDH1A1 | |
| SCHEMBL15768639 | 0.73 | CYP2A6 (0.44) | CYP2A6CYP3A4CYP2E1SMN1; SMN2GRM1 | |
| SCHEMBL12335152 | 0.73 | SMN1; SMN2 (0.57) | CYP2A6CYP3A4CYP2E1SMN1; SMN2GRM1 | |
| SCHEMBL12530492 | 0.72 | GRM1 (0.56) | CYP2A6CYP3A4CYP2E1GRM1ALDH1A1 | |
| SCHEMBL16872784 | 0.72 | KMT2A (0.53) | SMN1; SMN2MAPTRAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212160-A1 | 2,4,6-TRI-SUBSTITUTED PYRIMIDINE COMPOUNDS AS ATR KINASE INHIBITORS | BEIJING TIDE PHARMACEUTICAL CO., LTD. (CN) | 2023-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230212160-A1 | 2,4,6-TRI-SUBSTITUTED PYRIMIDINE COMPOUNDS AS ATR KINASE INHIBITORS | ATR, CHEK2, CHEK1 | CYP2A6 2976/4885CYP3A4 3195/4885CYP2E1 3753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.