Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.39 |
| ▸ | ACACB | O00763 | 3/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25823802 | 0.90 | PLA2G4B (0.40) | CA12CA1CA2CA9PLA2G4B | |
| SCHEMBL30490965 | 0.88 | ACACB (0.43) | CA12CA1CA2CA9ACACB | |
| SCHEMBL18591858 | 0.85 | KMT2A (0.43) | PLA2G4B | |
| SCHEMBL18282352 | 0.81 | CA12 (0.43) | CA12CA1CA2CA9PLA2G4B | |
| SCHEMBL28675412 | 0.80 | PLA2G4B (0.46) | CA12CA1CA2CA9PLA2G4B | |
| SCHEMBL18611917 | 0.78 | ACACB (0.48) | ACACBACACALMNAHPGD | |
| SCHEMBL24675649 | 0.77 | ACACB (0.43) | CA12CA1CA2CA9ACACB | |
| SCHEMBL24675533 | 0.77 | ACACB (0.43) | CA12CA1CA2CA9ACACB | |
| SCHEMBL24675884 | 0.77 | ACACB (0.43) | CA12CA1CA2CA9ACACB | |
| SCHEMBL18551107 | 0.77 | ACACB (0.43) | ACACBACACALMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |