Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 7/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | ACACA | Q13085 | 3/20 | 0.41 |
| ▸ | HRH2 | P25021 | 3/20 | 0.41 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18611917 | 0.89 | ACACB (0.48) | ACACBACACAHRH2HRH1HPGD | |
| SCHEMBL24675649 | 0.89 | ACACB (0.43) | ACACBCA12CA1CA2CA9 | |
| SCHEMBL24675533 | 0.89 | ACACB (0.43) | ACACBCA12CA1CA2CA9 | |
| SCHEMBL24675884 | 0.89 | ACACB (0.43) | ACACBCA12CA1CA2CA9 | |
| SCHEMBL18551103 | 0.89 | ITGB3 (0.46) | ACACBCA12CA1CA2CA9 | |
| SCHEMBL18551111 | 0.89 | ITGB3 (0.46) | ACACBCA12CA1CA2CA9 | |
| SCHEMBL25823802 | 0.89 | PLA2G4B (0.40) | ACACBCA12CA1CA2CA9 | |
| SCHEMBL18551107 | 0.89 | ACACB (0.43) | ACACBITGB3ITGA2BACACAHRH2 | |
| SCHEMBL25823808 | 0.88 | CA12 (0.41) | ACACBCA12CA1CA2CA9 | |
| SCHEMBL25410186 | 0.88 | ROCK1 (0.41) | ACACBACACALMNACTSKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129564-A9 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |