Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 8/20 | 1.00 |
| ▸ | AKR1B1 | P15121 | 8/20 | 1.00 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.67 |
| ▸ | MAOB | P27338 | 1/20 | 0.64 |
| ▸ | TTR | P02766 | 3/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | GMNN | O75496 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.63 |
| ▸ | ESR1 | P03372 | 1/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.63 |
| ▸ | APP | P05067 | 1/20 | 0.63 |
| ▸ | LCK | P06239 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20915006 | 0.92 | AKR1B10 (1.00) | AKR1B10AKR1B1ALOX5MAOBTTR | |
| SCHEMBL25302420 | 0.89 | AKR1B10 (0.81) | AKR1B10AKR1B1ALOX5MAOBTTR | |
| SCHEMBL1532424 | 0.89 | AKR1B10 (0.84) | AKR1B10AKR1B1ALOX5MAOBTTR | |
| SCHEMBL3249348 | 0.89 | AKR1B10 (0.84) | AKR1B10AKR1B1ALOX5MAOBTTR | |
| SCHEMBL1532425 | 0.89 | AKR1B10 (0.84) | AKR1B10AKR1B1ALOX5MAOBTTR | |
| SCHEMBL20914961 | 0.86 | AKR1B10 (1.00) | AKR1B10AKR1B1ALOX5MAOBTTR | |
| SCHEMBL2602741 | 0.86 | APP (0.85) | AKR1B10AKR1B1ALOX5TTRCYP3A4 | |
| SCHEMBL22577485 | 0.82 | ALOX5 (0.86) | AKR1B10AKR1B1ALOX5MAOBTTR | |
| SCHEMBL20915007 | 0.82 | AKR1B10 (0.75) | AKR1B10AKR1B1ALOX5MAOBTTR | |
| SCHEMBL20604716 | 0.82 | APP (0.83) | AKR1B10AKR1B1ALOX5MAOBTTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423429-B1 | MODULATORS OF LIPOXYGENASE AND CYCLOOXYGENASE ENZYME ACTIVITY | UNIV DE MONCTON (CA) | 2023-07-12 | — | — | EP | disclosed |