Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | DGKA | P23743 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8368795 | 0.88 | TSHR (0.64) | TSHRLMNAALDH1A1GAAKMT2A | |
| SCHEMBL11862242 | 0.88 | TSHR (0.64) | TSHRLMNAALDH1A1MAPTKMT2A | |
| SCHEMBL11860832 | 0.88 | TSHR (0.64) | TSHRLMNAALDH1A1MAPTKMT2A | |
| SCHEMBL1366448 | 0.88 | TSHR (0.64) | TSHRLMNAALDH1A1MAPTKMT2A | |
| SCHEMBL1363303 | 0.88 | TSHR (0.64) | TSHRLMNAALDH1A1MAPTKMT2A | |
| SCHEMBL1365915 | 0.88 | TSHR (0.64) | TSHRLMNAALDH1A1MAPTKMT2A | |
| SCHEMBL16059320 | 0.88 | TSHR (0.64) | TSHRLMNAALDH1A1GAAKMT2A | |
| SCHEMBL328762 | 0.88 | TSHR (0.64) | TSHRLMNAALDH1A1MAPTKMT2A | |
| SCHEMBL1363541 | 0.86 | — | — | |
| SCHEMBL5034229 | 0.81 | TSHR (0.54) | TSHRLMNAALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |