Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | MAX | P61244 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25826016 | 0.85 | EPHX2 (0.49) | MAPTHSP90AA1SMN1; SMN2EPHX2TLK2 | |
| SCHEMBL7472296 | 0.82 | MAPT (0.69) | MAPTHSP90AA1SMN1; SMN2IDO1TDO2 | |
| SCHEMBL7472301 | 0.82 | MAPT (0.69) | MAPTHSP90AA1SMN1; SMN2IDO1TDO2 | |
| SCHEMBL9053949 | 0.80 | EPHX2 (0.55) | MAPTHSP90AA1EPHX2GAAKMT2A | |
| SCHEMBL9098040 | 0.80 | EPHX2 (0.55) | MAPTHSP90AA1EPHX2GAAKMT2A | |
| SCHEMBL9097437 | 0.78 | EPHX2 (0.53) | EPHX2TGM2 | |
| SCHEMBL6855417 | 0.74 | HSP90AA1 (0.74) | MAPTHSP90AA1SMN1; SMN2KMT2ATGM2 | |
| SCHEMBL6833995 | 0.74 | HSP90AA1 (0.74) | MAPTHSP90AA1SMN1; SMN2KMT2ATGM2 | |
| SCHEMBL249878 | 0.74 | MAPT (0.55) | MAPTHSP90AA1SMN1; SMN2GAAKMT2A | |
| SCHEMBL249877 | 0.74 | MAPT (0.55) | MAPTHSP90AA1SMN1; SMN2GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023133375-A1 | MACROCYCLIC COMPOUNDS AND USE AS KINASE INHIBITORS | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2023-07-13 | — | — | WO | disclosed |