Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | TGM2 | P21980 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21238643 | 0.88 | MAPKAPK2 (0.42) | EPHX2BRD4MAPTHSP90AA1SMN1; SMN2 | |
| SCHEMBL21238708 | 0.88 | MAPKAPK2 (0.42) | EPHX2BRD4MAPTHSP90AA1SMN1; SMN2 | |
| SCHEMBL25825365 | 0.85 | MAPT (0.48) | EPHX2TLK2MAPTHSP90AA1SMN1; SMN2 | |
| SCHEMBL9098040 | 0.81 | EPHX2 (0.55) | EPHX2MAPTHSP90AA1TGM2KMT2A | |
| SCHEMBL9053949 | 0.81 | EPHX2 (0.55) | EPHX2MAPTHSP90AA1TGM2KMT2A | |
| SCHEMBL9097437 | 0.79 | EPHX2 (0.53) | EPHX2TGM2 | |
| SCHEMBL20726359 | 0.79 | PRKAB2 (0.42) | EPHX2MAPTHSP90AA1KMT2AGAA | |
| Formic Acid SCHEMBL27886080 | 0.73 | TGM2 (0.44) | EPHX2TGM2 | |
| SCHEMBL11519137 | 0.72 | MAOA (0.55) | EPHX2MAPTHSP90AA1KMT2AGAA | |
| SCHEMBL8363166 | 0.72 | MEN1 (0.61) | BRD4MAPTIDO1TDO2TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023133375-A1 | MACROCYCLIC COMPOUNDS AND USE AS KINASE INHIBITORS | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2023-07-13 | — | — | WO | disclosed |